BMC Shell protein trees

Shell protein phylogenetic trees represent an overview of the similarities among each type of BMC shell protein: BMC-P, BMC-H, BMC-Hp (permuted BMC-H), BMC-Ts (trimer, tandem fusion of BMC-H), BMC-Tsp (permuted Ts) and BMC-Tdp (permuted Ts, forms dimers of trimers). They are based on an overall alignment of non-redundant sequences and major subclades were labeled with color names chosen from the xkcd color survey (https://xkcd.com/color/rgb/). Proximity on the tree generally indicates a similar function that could be structural or related to the enzymatic function. Shell proteins from a BMC type therefore do not necessarily cluster in one position but are frequently found all over the tree. Multiple BMC-P usually follow a pattern of one protein each in the orange and grey clade and a third from one of the other major clades.

Different trees:
BMC-P
BMC-H
BMC-H
BMC-Ts
BMC-Tsp
BMC-Tdp

More information can be found in the following publications:
A catalog of the diversity and ubiquity of bacterial microcompartments
Sutter M, Melnicki MR, Schulz F, Woyke T & Kerfeld CA; Nature Communications 12, 3809 (2021)
Evolutionary relationships among shell proteins of carboxysomes and metabolosomes
Melnicki MR, Sutter M, Kerfeld CA; Current Opinion in Microbiology 62:19 (2021)