BMC type: GRM1A


Organism: Clostridium botulinum. Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;


   BMC-P    BMC-H/Hp    BMC-Ts/sp    BMC-Tdp    AldDh    PTAC    signature enzyme    AlcDh    regulator    others    no assignment

      ADU76_10920 (fasta)
           ADU76_10925 (fasta)
              ADU76_10930 (fasta)
               ADU76_10935 (fasta)
                   ADU76_10940 (fasta)
                        ADU76_10945 (fasta)
                          ADU76_10950 (fasta)
                                    ADU76_10955 (fasta)
                                           ADU76_10960 (fasta)
                                            ADU76_10965 (fasta)
                                             ADU76_10970 (fasta) H_sky GRM1A (HMM details)
                                              ADU76_10975 (fasta) H_periwinkleBlue GRM1A (HMM details)
                                                       ADU76_10980 (fasta) HMMalddh_2_egra GRM1A (HMM details)
                                                                       ADU76_10985 (fasta) HMMgre_1_grms GRM1B (HMM details)
                                                                             ADU76_10990 (fasta) HMMgreae_1_grms GRM1B (HMM details)
                                                                               ADU76_10995 (fasta) Hp_euts_oldRose GRM1A (HMM details)
                                                                                 ADU76_11000 (fasta) HMM10662PduV_1_mix GRM1A (HMM details)
                                                                                     ADU76_11005 (fasta) HMM01923cobtr_3_eut2 GRM1A (HMM details)
                                                                                          ADU76_11010 (fasta) HMM06723EutJMreB_1_grm GRM1A (HMM details)
                                                                                           ADU76_11015 (fasta) P_paleCyan GRM1A (HMM details)
                                                                                               ADU76_11020 (fasta) HMM06249EutQ_3_grm1 GRM1A (HMM details)
                                                                                                         ADU76_11025 (fasta) HMMalddh_2_egra EUT2B (HMM details)
                                                                                                             ADU76_11030 (fasta) HMMptac_1_mix GRM1A (HMM details)
                                                                                                              ADU76_11035 (fasta) H_fuchsia GRM1A (HMM details)
                                                                                                                ADU76_11040 (fasta)
                                                                                                                       ADU76_11045 (fasta)
                                                                                                                            ADU76_11050 (fasta)
                                                                                                                                 ADU76_11055 (fasta)
                                                                                                                                      ADU76_11060 (fasta)
                                                                                                                                         ADU76_11065 (fasta)
                                                                                                                                                     ADU76_11070 (fasta)
                                                                                                                                                        ADU76_11075 (fasta)
                                                                                                                                                         ADU76_11080 (fasta)
                                                                                                                                                          ADU76_11085 (fasta)

BMC shell protein types:

BMC-H(map on tree)

       H_fuchsia
       H_sky
       H_periwinkleBlue

BMC-Hp(map on tree)

       Hp_euts_oldRose

BMC-P(map on tree)

       P_paleCyan

(complete list of loci)

Protein sequences:

>ADU76_10920_UniProt_A0A0L7NAJ7
MIETLNINEVQSYSDSSNNNNYVQVTNNGQFTARFIITYVYNGTQVTANSENLAPCSVKKINIPSSANNVTTVVQVNDSTNWVPIYNNVAANGLDKLNLVLSGTIQAPLCTVIPNVPDVGDSPNPTMAVVQTVNPTAATVGQCITVTVAVTNHEGVTANGVNLQVQAPAESTFIPGSLMIAGVQSNLSEFPTGGITLGNIQEEATVTVVYQVLYNSVPQQANGPLLTAPQITYSFTGSNGSNQAGTLTGTTGTLTVTSGCQPPTCNPCCCCCCCCCPSTSSMYNSYNQCM

>ADU76_10925_UniProt_A0A0L7F5B6
MIYTITFNPALDYVIKVEDLRLGNLNRTNFEGVYPGGKGINVSIVLNNLGIENIAFGYIAGFTGVEIEKRVNELGCATDFIKLDTGMSRINIKLQSNEETEINGKGPKISEDDLNNLFNKLDKLNEKDFLILSGSIVDTIPQNIYEVIMARLKEKDIKFVVDATKELLLSVLKYKPFLIKPNHHELGELFNVQLKNQEEVISYGTKLQKMGAENVLISMAGDGAIFISSTGEVMRSTVPRGILKNSVGAGDSMVAGFIAGYIKNNRLDYAFRMGVATGSASAFSDKLATKVEVEGLLDQVKIF

>ADU76_10930_UniProt_A0A0L7F4W5
MMSNECLNQMCCPSSCMYPTQSYIAPTQCCMPSTQCCMTPSQCCMNCCCCCCHCNNVGTPPPSNGETSGDWGPLHWEINYNIDPSDIYKDSFKIKITLSGVSIVDTELDAQHPKLNINLTISGVGIIGELGVDFVNRLVYLKGNLNFIFYQKAFNLVLLRF

>ADU76_10935_UniProt_A0A0L7F4W2
MRKKILSTSLAIMFLLTSLLFTGCGQKKETNLQKVRLNEVVRSVFYAPMYVAINEGFFKEQGLDIDLSTGQGADAPMFKTQV

>ADU76_10940_UniProt_A0A0L7EUT5
MCILAKYEPASNVGKYSWDYKLEHEYSALDKINMCLIELEDLKEFTDNHRKHYYAIAPLRGDGKIRRKLKEKEFIKYNWIKIDFLDIQEESKNYFETIEDRVTSYYFTEINKDTKFHYINNNYFEWYNLYIIVSEKELSGYEINNMFSQIYYFNMVKSNSLFDYIILKNIGFINLDVSFFHEEYSHENQRIGKGEKILMYYYPRNLE

>ADU76_10945_UniProt_A0A0L7EIQ4
MCSLTEKILYISNMEYKFFLNKANVIGVGLGYKIKNGFCYYKECIKIFVTKKIAENKLSDNDLVPKCFKGIETDVNEIGFQSMYSLRDRKRPVTGGYNISPTIGAESGTLGCIVTDGKYYYVLSNNHILASNGKTPINCPIIQPSRKYKGKDPNDIIANLSKYIIIKKSTPTEVEENFVDCAIAKITRRSYISTKITFLGRIKGTKAPRLYEKVQKVGCTTELTQGQISSIGTTIITDIMEEQTLFKNQIITNKMASGGDSGSILLDKNMNAIGLLMSGGSSSNTYNPISAVLDSLNVKIVVG

>ADU76_10950_UniProt_A0A0L7F5C2
MNNTMIQNSCNDSYVQVTNYGGYFAEFYVSYISNGQPIKESSGVFALGETRKIQIEPGTEGVLLQIDVWFLSAPKTIYNKYIETYTSDCFRLYGSIFNPSVAKVDCTDDDPPCYSACCNCCNAYNVCQCRNLYK

>ADU76_10955_UniProt_A0A0L7F4X0
MIAAIYARKSMETDKGESIENQIYLCKEFGTRAGATDFLYYKDEGFSGGNTNRPKFKEMIQAAKSNKFSMLICYRLDRISRNVADFSSTLETLQKHNIDFVSIKEHFDTSTPIGRAMVYIASVFAQLERETIAERIRDNMFELAKTGRWLGGTTPLGFKSEAINYIDFNGKNKKMYKLIEIPEEIELIKLIFNLYLEKKGFPSVANYLCSHKYKGKNGGEFSQGTIKQIIENPVYTYADEKIYKYFKDKGAILCGNFDGKHGVITYNKKEKGKKTNPINEWIISVGKHKGIISSDVWIKCQNINSLNSKKSSPRSATGNKFLLSGLLVCNECGSTMGSWSRNNPKSGKYEKYYRCNLKNRASNRCSSKMLNAYKAEDLVLSSIKGVTLNDLIEAYDDIINNKNALTSIKEKQNKLSKEIENNNKIIHGLIRKLALLDDDPTIISEFKKEINNLNKQNTSLKKEINSLEKSIKNTNSNANSIDEINAKIKNFKTLCDSTTDTEKLRSYLLEIINYIVWDSKTSTLKINLFNASSHVPIGGIRRQKDNLSFGNSSR

>ADU76_10960_UniProt_A0A0L7PEW7
MSEDSRAVSAEAIAAKKKLTRNFFRKGISLALFSGVSYGLYTAFLTMGMTKGVWNDWYGKNTAGLSAFIIAYLLAALGNAINDTCSAVWSLLYAIVKGKFGDFLRCINTKPGRIMIVAALIGGPIASTAYVVALQMAGSIVVPISALCPAIAAILGKVLYKQELNKRMAFGIGICVCASFLIGSTGFTGEASKGTLLGLLIAIIAALGWGFEGCVAGYGTALIDPEIGICIRQVTSGIANLFILLPILGKMAGGVNISVNLAVQAFTSSPAMAWFVLSGLLTFLTFMTWYAGNSMCGAGLGTACNGTYSFFGPLFCLLVLGVYGGMDGWSLPSVAWIGAIAMMIGILIVSMNPLDLFKKKTGVDIDEAA

>ADU76_10965_UniProt_A0A0L7PCJ5
MKPLNYAILKYFTKVEEACADDIIEALKGEYENFKALKRNAVINALLTAEANGLIEETRFDLDENKRLRVYYHANEDGVATINKYIKD

>ADU76_10970_UniProt_A0A0L7DXS7
MRYYGEEALGLVETVGLVPALEAADKMLKAANVELISYENIGSTLVTIVVKGDVGAVRSAVEAGAAAAASIGKLTAHNVMPRPIRAVGDIVSVHDIDS

>ADU76_10975_UniProt_A0A0L7PIG3
MARYEAIGSIETFGLVFALEAADAMCKAADVELIGYENVASGYISVLVRGDVGACKTAVDAGIAAVNTMEGANLYSSVVIARPHEDLEKIIKRYAVESLIPE

>ADU76_10980_UniProt_A0A0L7NNX3
MNINIIDNDLLSMQEARILVENAREAQKKLATFSQEKLDEIVERMIEEIEKHLNELAKLSNEETEYGKSEDKYMKNYFVCKYLKDRLKGMKCVGIINEDKVNRTMDIGVPKGVIIAFCPSTSPVSTTIYKTLIAVKSGNAIIFSPNPRAKKTISKTIDILIRVAEGIGLPEGAIAYLHTVTKSGSLELMNHKDTSLIMNTGVLEMLHDAYKSGKPVIYGGNGNGPAFIERTADIKKAVKDIISSKNFDYGIVSASEQSVVVDSLIASEVKQEFIKNGGYFMTEDESAKLGSVLFNKDGSFDIELIGKSPQFLAKTAGFTISQDIKVLISKQKFVSKKNCYSREKLCPVLAFYIEEDWMHACEKCIELLLTEKYGHTLSIHSKDEEVIRQFALKKPVGRILVNTPGTFGSMGATTNLFPSMTLGSGSAGKGMTSDNVSPMNLVYIRKVGYGVREIDEIVKMVNNTNDSNCEFSDDRVDKKEIDNYELLESILKKVLEELN

>ADU76_10985_UniProt_A0A0L7F4L8
MDIREFSNRFMEATKNMSEEERASLMKMFASVSKEITKEDKASSSATENNNGEIPNGMTERLKKLKENYLKQIPSITTYRAKAITKIAKENPGMPKILLRAKCFKYCCETAPLLIQDNELIVGAPNGKPRAGAFSPDIAWRWMVDEIDTIGNRAQDPFYISEEDKKVMREELFPFWKGKSVDEYCEDQYREAGVWELSGESFVSDCSYHAVNGGGDSNPGYDVILMKKGMLDIKREAEEKVSNLKYENPEDIDKIYFYKSVIDTADGVMIYAKRMSDYAKELAEKETDPKRRSELQKISEVNAKVPAHKPTNFWEAIQAVWTIESLLVVEENQTGMSIGRVDQYMYPFYKADIESGRMNNFEAFELVGCMLIKMSEMMWITSESGSKFFAGYQPFVNMCVGGVTREGLDATNDLTYLLMDAVRHVKIYQPSLACRIHKASPQKFLKKIVDVIRAGMGFPACHFDDVHIKMMLSKGVSIEDARDYCLMGCVEPQKAGRLYQWTSTAYTQWPICIELALNHGVPLWYGKQVCPDMGDLSKFKTYEQFEAAVKEEIKFVTKWTSVATVISQRVHRDLAPKPLMSIMYEGCMEKGKGVEAGGAMYNFGPGVVWTGLATYTDSMAAIKKLVFDDKKYTLQELNEALKADFVGYEKIRKDCIEAPKYGNDEDYADYIAADLIGFTEREHRKYKTLHSVLSHGTLSISNNTPFGQMTGASANGRKAWMPLSDGISPSQGSDYKGPTSIIKSVSKMSCENMNIGMVHNFKLISGLLDTKEGEQGIITLLRSACALQLGEVQFNYLDNKTLIEAQKHPEQHRDLIVRVAGYSAFFVELCKDVQDEIISRTMLTHF

>ADU76_10990_UniProt_A0A0L7PCK1
MSNANLGVIERKARIFNIQKYNMYDGNGIRTLVFFQGCPLRCKWCANPEGMIKKYRVMFKSNLCINCGACVSACPVGIHTISNSKHVINRDIDCIGCKKCKEACLKSAISIVGETKTISELLRIIEEDRTFYEMSGGGVTLGGGEVLMQPEAATSLLMACKQEGINTAIETCGYTNKETILKVAEFTDLFLFDIKNIDSDKHFKLTGVRNEQILENLEELLYKKYNVKIRMPLLKGINDSQNEIEKTMEFLIPYKEYKNFKGIDLLPYHKMGVNKYNQLGIEYPINGDPSLSNEDLDRIEGWIKKYDLPVRVIRH

>ADU76_10995_UniProt_A0A0L7PF24
MGDFFDKNIQRIIQESVPGKQITIAHVIASPMTDIYERLGIDEKGAIGILTLSPFETAIIAADIATKASDVEIGFLDRFTGSVVISGDVQSVETALIAVNNTLKDMLGFTQAPITRT

>ADU76_11000_UniProt_A0A0L7EJZ1
MRKKRIMVIGPSRCGKTTIVNSLNDYDGPLRRTPDLIYGKNTIDVPGSYIENPWMYKHVIAISQDASHVLILVDQSNCNEVYSYGFAKSFRCPVIGIITKCDLMPDNEDKCLRQLKNIGVKEPYFHISFPMGLGIDALKEYLKR

>ADU76_11005_UniProt_A0A0L7F4M4
MVKFITEEHLRELYRKKPFNIYKLEQEQRLTPGAVEYLSDKKIKISKDTCDNFKEILKANIKTSQDIRVDTTKEEENRNLNLKKRLCYKLKSIEAKFLVTTSEILKEDVILAQGIMNLNRKIANIRNVLDGKDTLESISFKECRGMNLSNFTIEIGDCFEITEFHMQLKKSNVILKMNILRCMLRELQLEILETYKEDDLKNTIISNFNSIINSLSQLICLAVGGKECQRKI

>ADU76_11010_UniProt_A0A0L7EKB4
MSKENLTFEYCDEMVKKFEEVIEKPVINESSIYYTGVDLGTACVVIAVLDENYNPVAGAYRYADVVRDGMVVDYIGAVRIVRELKEEIEEKLNTELIYAAAAIPPGTDALDSGAIKNVVQSAGFELTCLLDEPTAANAVLKIKNGAVVDIGGGTTGISILKNGEVVYVVDEPTGGTHFSLVLSGAYKIPFKEADEFKRNNKNHKEILPILKPVVEKISSIINKYIRNYDVNELSLVGGTCCLTGIEDIIEKNTGVHTHKPKNPMFVTPLGIALSCTQDII

>ADU76_11015_UniProt_A0A0L7PFK2
MIAAKLIDNVWATRKSESLSGLKFMLAEEIGGIDAGRRFIVVDIIGAGIGDRVIVSSGSSARRMLGNDNIPVDAAVIGIIDEDCNFG

>ADU76_11020_UniProt_A0A0L7NFR4
MKKLICTKDVEKVITDEEKIFYIDGSEIITPAARDFAKNNGIVFKIKTNESKIEKIVNKKDLNMENFDCEMMLNLFKKMMDKGLLKEMLQCLKQDNFPFEVERHSSGLKVVRGNTVKMDVFDTGNPDAKVYFQELVNKDESKISAGFLIIDNSKFDWELSYEEIDYVIEGTLAIEINGKTYVAYPGDVLFVPSGSRVVWSSPDKARIFYATYPANWADLL

>ADU76_11025_UniProt_A0A0L7F555
MGNIDKDLCSIQQARDLARLGKIAADKIANYTEEQIDKILRNMVRVAEENAGYLAEMAVKETGFGKVFDKAYKNHLASTVVYNSIKDMKTIGIIEKDKKNKIIKIAEPVGLILGIVPSTNPTSTAIFKAIISIKSRNAIVFSPHPSAKKCTVKALELMRDAAIEAGAPENIINCITTPTLEATNELMKCKEVSMIIATGGPGMVKAAYSSGKPALGVGAGNSPAYIERTANVEKAVRDIISSKTFDNGTICASEQSIICEECNLDKVVEEFKKQGGYFMTEEETLKVCRLLFKNGHTMNAKFVGRSPQVIASAAGFIVPEETKLLIGKQNGVGEGNPLSFEKLTTVLAFYTVKDWQEACELSIELLQNGIGHTMSLHTEDDDIVMKFARKPASRILVNTGGSQGGTGATTGLSPAFTLGCGTWGGSSTSENVTPEHLINIKRVAYGLKDCTTLVEDDKTFNYIKKNRYGNTECCNEVEKQFMDMSPAQIKAASEWLNNNNCTKDVNKCTENANVYTENNNEGTKNQELLELVNQIVAAMKGAN

>ADU76_11030_UniProt_A0A0L7DUI1
MESCEEVLKLLLEFVEESRNFNSYKSSLEIPVGISNRHVHLSQKDLDILFGKDYHLVKIKDLSQPGQFASKETVTICGPKGAIEKVRILGPVRSKTQVEVLNGDCIKLGVSQHVRLSGNTTKTSGITIIGPKGSVQIEEGVIVAQRHIHMTPKDAKTFGVHDGETVSINLDTLRGGIYKNVIIRANDTSRLECHIDIEEANAMGINSKSKITIIK

>ADU76_11035_UniProt_A0A0L7NFN2
MKFDALGMIETKGLVGSIEAADAMVKAANVYLIGKEYIGGGLVTVMVRGDVGAVKAATDAGAAAAQRVGELISVHVIPRPHSEVEGILPSVKEVAK

>ADU76_11040_UniProt_A0A0L7PAT9
MKYVFEESVAYMLNKVVLKIKKELTSRFNKYDVTIEQWRLLTRLWKVDGISQTQLAIRCSKDLPTVTRMLDKLEKKEVIERKEDPNDSRAYLVFLTEKGKGLEEKLDPIAYEIENKSIQNVRKEDIEVVKKVLDIMITNLD

>ADU76_11045_UniProt_A0A0L7PF33
MNESKSIWTKNFILIILGNLLMFVSHYFLVSSLPLYITETLNGNEKLVGYVIGIYCLVSVITRPLSGYMLDNICRKKIVIFALIMYVLCLKYYILASGFLVLLIIRGVQGFFWGFTSTGFGTIAADLIPCEKTGEGLGYYGISSTIAMAIGPSIALIIIKHGSFSKLFNTGLVFGILALISLLFVKYDENINKKAKKNGKINISDFFEKEVFWLASIMFFIAITFGAIISFIIIYGKQIAVTNPGKFFSIYSTILLCIRPFAGKYFDKNGPVKIMALGFVGGILSFTLLFFAKGDILFDLAAICMGIMHGICAPSIIAMAINRVDDTRRGTANATILSAQDLGIGIGPMILGNLSNVIGLAGMYLVCAVIMIIPLVIFYLKETKVYEDLSDVEKVM

>ADU76_11050_UniProt_A0A0L7EK39
MINGFYTNQKCIAVFVIKKVPCSELLSNEIIPRCYKGFQTDVNECEMPVCNSLRTRIRPVLNGYSVGNILKKSSGTAGCLVADKYLYILSNNHVFALNNQAPIGSVILQPSVEDGGKIEKDVIGHLNRYIPIKFIEGKTKPENTVDCALCKVINRSFVSPKIAFVGSPKGTAKAKLNEDVIKIGRTTALTTGKIKYLSATFEVDCLYVDKPALFKDQIITTKMAGPGDSGALLLNKDNYAVGLLIGSNSNLVAFNPIEAVLDSLKVKLVTA

>ADU76_11055_UniProt_A0A0L7F3T3
MVNEFYTKQKCIIVFVTKKVPCSELLSSEIIPNCYKGFQTDVKECEMPICNSLTTKVRPVINGYSVGNILKYNSGTSGCLVADKYLYILSNNHVFALSNEAPIGSVILQPSVEDGGKIEKDVIGHLNRYIPIKFIEGKTKPENIVDCALCKVINRSFVSSEIAFVGTPKGTAKAKLNEDVKKVGRTTELTIGQVKYLYATFIVNSLQIGKKALFTNQIITTKMAEPGDSGALLLNENNYALGLLIGSNNDIGVFSPIQKVLDSLKVKLVTS

>ADU76_11060_UniProt_A0A0L7F484
MINGFYTCEKCITVFVTKKLSCNELLSNEIIPRCYKGFQTDVKECGMPICDALKTRVRPVINGYSIGNILENNYGTAGCLVADKYLYILSNNHVFALNNRAPIESVIVQPGVNDGGKIEKDVIGHLNRYIPIKFIEGKTKPENIVDCALCKVISRSFVSPKIAFVGIPKGTAKAKLNEDVKKVGRTSELTTGKIKNLSATFTVACSQVGKLALFKNLIVTTRMGQPGDSGSLILNEDNHAIGLYVGSINDITIANPIEKVLDSLKVKLVTA

>ADU76_11065_UniProt_A0A0L7EKC6
MQNINLSNKYNIRKLFKDNEYIVEKLCEKCSDYYILHDGIIPSKQKVKEIFIALPPNKNYKDKFVLGVYKFDELVGIVDIVKKFPTMGEWMLGLIVIDPEERGNGLGKRVHKELVAWAKALGAKSFRVGVIEENYKGIKFWSSLGYKKIKEINMDFIAKTHVVNVMRLKLNNM

>ADU76_11070_UniProt_A0A0L7NGI1
MNKKYSNLFDPIKIGDLEIKNRFVMAPMGPAGLCSEDGSFNEKGIEYYVERAKGGTGLIITGVTYVENDIEKCAMPSMPCPTINPSSFIKAAKVLTERVHAYNSKIFLQLTAGFGRVSIPGIVGDITPIAPSPIPHKWIPDITCRPLTIEEIQIYIKKFGESAAIAKEAGFDGVEVHAVHEGYLLDQFTMTLFNKRTDKYGGSLENRLRFPIEILKEIKEQCGVNFPVSLRYSVKSYVKGLNDGALPGEDFEEKGRDLAEGLEAAKILEKAGYDAFNSDAGTYDSWYWNHPPMYFKKGMYLSLNEKLKQVLKVPVITAGRMDNPDLASDAISTNKTDMIALGRPLLADAYIPEKIRQDKLKNIRPCLSCHDGCMGRLALGGGLSCAVNPSTGREKEFKLEPATEIKNVLVIGGGVAGCEAARVCAIRGHKVSLYEKTDKLGGNIIPGGTPDFKEDDRALVKWYYNELKENKVDIHFNTTVTEELANNPNYDVVIVATGSNPKLLQLNGNMDKVYTAQDVLLKSEDAGNSSVIIGGGLVGCETALWLVQQGKNVTLIEALDEILASGPAICHANSQMLKDLLKFHKVDIKTNCLVSKVTDEGIVIKQNDKEIPISCDSVILSVGYTSEKDLYEKLKFTNKEMYLLGDAKQVQNIMTAIWDAYEVARNI

>ADU76_11075_UniProt_A0A0L7F462
MQEPTKRQIQAMNTKKKLYDISTDLMKTKGYDNVTIQEICKKAGVSVGSFYHYFESKNDIFIELYKIADDFFYDTIKGKLSSEDTINKIIEYFNYYAEYNEKMGIDMMKQLYNSNNKMFITKGRHMQTVLDTIIEQGQKNNEVTTEMTPKQITRFLFVLMRGVVYDWCLHDGEYDLKEKMKSMLMQILKTIKP

>ADU76_11080_UniProt_A0A0L7EFA7
MACILIIVPTVNSVFKPTFFTTSFNLGIIGDCGIPTNAILGDTKDLFITLAMAQST

>ADU76_11085_UniProt_A0A0L7F4P1
MYNFGLEQPILVHNFKYQIKWTGELYMNKENTRAVILAVFTFIVTFIGSAEIYKLIEKIGLGN